Efficacy and Safety of Silodosin, Mirabegron, and Tadalafil as Medical Expulsive Therapy for Lower Ureteric Stones: A Prospective, Randomized, Comparative Study

Purpose: We aim to evaluate and compare the efficacy safety of Silodosin, Mirabegron, Tadalafil as a medical expulsive therapy (MET) for lower ureteric stones in adults. Material Methods: A total number 150 cases who had unilateral single stone between December 2021 August 2022 were incorporated this prospective randomized comparative study. The patients randomly divided into 3 equal groups. first group received Silodosin medication, second Mirabegron third medication. medications would be continued until expulsion stone, maximum weeks. duration each patient was no longer than treatment or weeks, whichever came first. success considered if passed during weeks treatment, did not pass that failure underwent ureteroscopic intervention removal. Results: Altogether 50 (33.3%) 1 (Silodosin group), 2 (Mirabegron (Tadalafil group) enrolled Expulsion rates groups 1, 2, 86%, 72%, 78%, respectively, however, significant difference (p-value > 0.05) determined. Conclusion: While none noticeably better others, silodosin, mirabegron, tadalafil showed increased distal ureteral stones.